Xenon Pharmaceuticals continues to demonstrate strong momentum, with successful patient randomization in its Phase III X-TOLE2 study for azetukalner, while also expanding its therapeutic focus beyond epilepsy.

• Completed successful randomization of 380 patients for the Phase III X-TOLE2 trial, exceeding initial targets.
• Top line data readout expected in early 2026, maintaining high confidence in positive outcomes based on historical study results.
• Evaluating broader therapeutic applications for azetukalner in major depressive disorder and bipolar depression, supported by robust preclinical and clinical evidence.
• Advancing early-stage pipeline with promising candidates in ion channel programs, signaling growth potential beyond current epilepsy focus.